Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats
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چکیده
منابع مشابه
Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats
BACKGROUND Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. METHODS In this study, we prepared levodopa methyl ester (LDME)/benserazide-loaded nanoparticles, which can re...
متن کاملLevodopa-induced dyskinesia and thalamotomy.
Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviated almost completely by stereotaxic surgery using a microelectrode technique for the ventralis oralis anterior and posterior nuclei of the thalamus, but much less by the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesion...
متن کاملLevodopa-induced dyskinesia and striatal signaling pathways.
P arkinson’s disease (PD) is the most common movement disorder, affecting 2% of individuals over age 60 (1). The cardinal clinical features of PD are resting tremor, rigidity, bradykinesia, and postural instability, which are often accompanied by autonomic, cognitive, and emotional disturbances. The neuropathological hallmark of PD is the degeneration of dopaminergic neurons in the substantia n...
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Although levodopa therapy remains the most effective symptomatic treatment for PD, its usefulness may be limited by these motor complications, which result in deterioration in quality of life. Levodopa-induced dyskinesia (LID) is characterized by a variety of hyperkinetic movements. Although chorea and dystonia are the most common manifestations of LID, stereotypies, tics, myoclonus, or ballism...
متن کاملSustained release antiparkinson agents: controlled release levodopa.
The rationale for sustained release oral levodopa preparations is to deliver levodopa in the areas of maximal intestinal absorption in a slow and predictable way, leading to stable plasma levodopa levels and brain dopamine levels, therefore resulting in a lengthened duration of action. Sinemet CR is the prototype of such preparations, with demonstrated efficacy in decreasing periods of akinesia...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2012
ISSN: 1178-2013
DOI: 10.2147/ijn.s30463